Assessment of transthyretin cut-off values for a better screening of malnutrition: Retrospective determination and prospective validation

The use of transthyretin (TTR, prealbumin) as a marker malnutrition and the definition associated cut-offs are matter debate. In order to clarify this issue, we performed retrospective study then prospective validation one. first study, data from 23,617 consecutive patients our University hospital were analysed. Using 0.11 0.05 g/L cut-off values defined by French Health Authority, only 3.13% 0.49% appeared malnourished or severely indicating that these clearly inappropriate. stratified for normal (?0.2 g/L) low (<0.2 TTR, (<15 mg/L) high (?15 C-reactive protein, hence defining 4 groups (n = 50 57/group), analysed according nutritional status estimated patient files. Receiver operating characteristic (ROC) curve TTR level with allowed setting at 0.17 0.12 severe respectively.